The CBSE Class 12 Biotechnology Sample Paper 2026-27 has been officially released by the Central Board of Secondary Education (CBSE) on its official portal (cbseacademic.nic.in). Students preparing for their upcoming Class 12 Biotechnology board examination can now download the official sample question paper and marking scheme and solution key. Practicing the official model paper is important to understanding the paper pattern, unit-wise weightage, assertion-reasoning questions, numerical weightage, and paper difficulty level. Check the direct PDF download links, detailed exam pattern, syllabus distribution, and download instructions in the article below.
CBSE Class 12th Biotechnology Sample Paper 2026-27 Overview:
The sample paper for Biotechnology(045) which is a core scoring subject for Class 12 Arts/Humanities stream students. The subject requires a clear conceptual understanding of Genetic Engineering, Recombinant DNA Technology, Molecular Biology, Cell Structure and Function, DNA,RNA and Protein Synthesis, Biotechnology Applications. To guide students in their board preparation, CBSE provides official Sample Question Papers (SQP) and Marking Schemes (MS) every year. By solving the CBSE Class 12 Sample Paper 2026-27 PDF, students can check their speed, practice exam level questions, and improve their answer presentation skills before the final examination, which will help them to score high and boost their preparation strategy.
| Particulars | Details |
| Board Name | Central Board of Secondary Education (CBSE) |
| Exam Name | CBSE Class 12 Senior School Certificate Examination 2027 |
| Subject Name | Biotechnology (Code: 045) |
| Academic Session | 2026–2027 |
| Total Marks | 100 Marks (Theory: 70 Marks + Project Work: 30 Marks) |
| Exam Duration | 3 Hours (180 Minutes) |
| Format | Online Downloadable PDF |
| Official Website | cbseacademic.nic.in |
CBSE Class 12 Biotechnology Exam Pattern 2026-27
The CBSE Class 12 Biotechnology Exam 2026-27 will carry a total of 100 marks, including 70 marks for the theory examination and 30 marks for practicals. The theory paper will be conducted for 3 hours. It will include multiple-choice, short-answer, case-based and long-answer questions to test students’ knowledge and understanding of Biotechnology.
As per the official CBSE sample question paper, the theory examination will have five sections, from Section A to Section E. Students must attempt all questions, while internal choices will be available in some questions.
| Particulars | Details |
|---|---|
| Board | Central Board of Secondary Education (CBSE) |
| Class | 12th |
| Subject | Biotechnology |
| Subject Code | 045 |
| Academic Session | 2026–27 |
| Total Marks | 100 |
| Theory Marks | 70 |
| Practical Marks | 30 |
| Theory Exam Duration | 3 Hours |
| Question Paper Sections | 5 |
| Question Types | MCQs, Short Answer, Case-Based and Long Answer |
| Internal Choices | Available in some questions |
CBSE Class 12 Biotechnology Theory Paper Pattern
The theory question paper will contain 33 questions divided into five sections. The distribution of questions and marks is given below:
| Section | Question Type | Number of Questions | Marks per Question | Total Marks |
|---|---|---|---|---|
| Section A | Multiple Choice Questions (MCQs) | 16 | 1 | 16 |
| Section B | Short Answer Questions | 5 | 2 | 10 |
| Section C | Short Answer Questions | 7 | 3 | 21 |
| Section D | Case-Based Questions | 2 | 4 | 8 |
| Section E | Long Answer Questions | 3 | 5 | 15 |
| Total | 33 | 70 |
CBSE Class 12 Biotechnology Sample Paper 2026-27 PDF with Solutions
Students preparing for class 12 Biotechnology examination will get an exact clear image of the question patterns, marking schemes and marks distributions which will help them to enhance their examination preparation.Students can directly download the official CBSE Class 12 Biotechnology Sample Question Paper 2026-27 on its official website or from this article:
| Resource Name | Direct Download Link |
|---|---|
| CBSE Class 12 Biotechnology Sample Question Paper 2026–27 PDF | Biotechnology Sample Paper 2026 |
| CBSE Class 12 Biotechnology Official Marking Scheme / Solutions PDF | Download PDF |
Important Topics Covered in CBSE Biotechnology Sample Paper 2026-27
- Protein Engineering : Enzyme activity, serine proteases, protein modification- Conceptual MCQs
- Microbial Culture : Growth phases, turbidostat, specific growth rate- MCQs, numerical questions
- Plant Tissue Culture : Meristem culture, callus induction, somatic embryos – MCQs, assertion-reason
- PCR & DNA Technology : Primers, DNA amplification, recombinant DNA- MCQs, short answers
- Animal Cell Culture : CHO cell lines, cell culture media, monoclonal antibodies- MCQs, application-based
- Genomics & Proteomics : Microarray, gene expression, genome analysis -Sequence-based MCQs
- Genetic Manipulation: Vectors, transformation, DNA fingerprinting – Conceptual and application questions
CBSE Class 12 Biotechnology High-priority Topics for Board Exam 2026-27
- PCR and its components
- Recombinant DNA Technology
- DNA Fingerprinting
- Microbial Growth Kinetics
- Plant Tissue Culture
- Protein Engineering
- Animal Cell Culture
- Microarray Technology
- Monoclonal Antibodies
- Genetic Manipulation
Benefits of solving CBSE Class 12 Biotechnology Sample Paper 2026-27
Here are some of the benefits mentioned below:
- Understand the CBSE 12th exam pattern and marking scheme.
- Understand the difficulty level.
- Understand the type of questions asked in the CBSE Class 12th Biotechnology exam 2026.
- Find the weaker areas that need more attention.
- Improve the confidence of the learners.
- As a revision Tool: Marking Scheme with solutions can use them as a revision tool.
- For Self- Assessment: Sample paper will give you the benefit for self assessment.
- Time Management.
- Practice question paper.
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