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    The most effective pharmacophore that confers antibiotic activity to penicillin G is
    Question



    The most effective pharmacophore that confers antibiotic activity to penicillin G is

    A.

    phenylacetamide

    B.

    thiazolidine ring

    C.

    carboxylic acid

    D.

    beta-lactam

    Correct option is D

    Benzylpenicillin, also known as penicillin G (PenG) or BENPEN, is an antibiotic used to treat a number of bacterial infections. Due to benzylpenicillin's limited bioavailability for oral medications, it is generally taken as an injection in the form of a sodium, potassium, benzathine, or procaine salt. Benzylpenicillin is given by injection into a vein or muscle. Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle only.
    Benzylpenicillin has relatively low toxicity, except for in the nervous system, in which it is one of the most active drugs among β-lactam agents.
    β-Lactam antibiotics ( beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives (penams), cephalosporins and cephamycins (cephems), monobactams, carbapenems and carbacephems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics.
    β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused susceptible organisms. 
    β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. 

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