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The major product formed in the following reaction is
Question

The major product formed in the following reaction is

A.

B.

C.

D.

Correct option is C

Asymmetric hydrogenation is a chemical reaction that adds two atoms of hydrogen to a target (substrate) molecule with three-dimensional spatial selectivity. Critically, this selectivity does not come from the target molecule itself, but from other reagents or catalysts present in the reaction. This allows spatial information (what chemists refer to as chirality) to transfer from one molecule to the target, forming the product as a single enantiomer. The chiral information is most commonly contained in a catalyst and, in this case, the information in a single molecule of catalyst may be transferred to many substrate molecules, amplifying the amount of chiral information present.

​Chiral phosphine ligands, especially C2-symmetric ligands, are the source of chirality in most asymmetric hydrogenation catalysts. Of these the BINAP ligand is well-known, as a result of its Nobel Prize-winning application in the Noyori asymmetric hydrogenation.

The BINAP/diamine-Ru catalyst is effective for the asymmetric reduction of both functionalized and simple ketones.

Some catalysts operate by "outer sphere mechanisms" such that the substrate never bonds directly to the metal but rather interacts with its ligands, which is often a metal hydride and a protic hydrogen on a ligand. As such, in most cases dihydrogen is split heterolytically, with the metal acting as a Lewis acid and either an external or internal base "deprotonating" the hydride. For an example of this mechanism we can consider the BINAP-Ru-diamine system. The dihalide form of the catalyst is converted to the catalysts by reaction of Hin the presence of base:

​​The "Noyori-class" of catalysts are often referred to as bifunctional catalysts to emphasize the fact that both the metal and the (amine) ligand are functional.


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