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    Question

    Which one of the following statements is TRUE?

    A.

    A, B, and Z DNA helices are left-handed.

    B.

    A, and B DNA helices are right-handed, Z DNA helix is left-handed.

    C.

    A, and Z DNA helices are left-handed, B DNA helix is right-handed.

    D.

    A, and B DNA helices are left-handed, Z DNA helix is right-handed.

    Correct option is B

    Correct Answer: (2) A, and B DNA helices are right-handed, Z DNA helix is left-handed.

    Explanation:

    • A-DNA and B-DNA are both right-handed helices. B-DNA is the most common form under physiological conditions, while A-DNA typically forms under dehydrated conditions.

    • Z-DNA, in contrast, is a left-handed helix. It forms under specific conditions such as high salt concentrations or supercoiling stress, and it plays a potential role in biological processes like gene regulation.

    Information Booster:

    1. A-DNA is a right-handed helix, formed under conditions of dehydration, with 11 base pairs per turn.

    2. B-DNA is the predominant form of DNA in vivo, exhibiting a right-handed helix with approximately 10.5 base pairs per turn.

    3. Z-DNA is a left-handed helix with 12 base pairs per turn. It forms under specific conditions, such as negative supercoiling.

    4. Z-DNA is thought to be involved in gene regulation and transcription processes, although its exact biological function remains under research.

    5. A-DNA and B-DNA are critical for most biological functions, such as replication and transcription.

    6. The structure of Z-DNA is significantly different from A and B forms, with a zigzag backbone instead of the usual double helix.

    Additional Information:

    • Option 1: A, B, and Z DNA helices are left-handed. This is incorrect because A-DNA and B-DNA are right-handed, while only Z-DNA is left-handed.

    • Option 3: A, and Z DNA helices are left-handed, B DNA helix is right-handed. This statement is incorrect as A-DNA is right-handed under standard conditions, and only Z-DNA is left-handed.

    • Option 4: A, and B DNA helices are left-handed, Z DNA helix is right-handed. This is incorrect because A and B-DNA are both right-handed, while Z-DNA is left-handed.

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