Correct option is D
Explanation-
Statement A -Cholecystokinin (CCK) produced from small intestine stimulates food intake - Incorrect
CCK is secreted by the duodenum in response to fat/protein. It induces satiety, inhibits gastric emptying, and reduces food intake. So, it actually inhibits rather than stimulates food intake.
Statement B - Leptin produced in adipose tissues stimulates food intake - Incorrect
Leptin is secreted by fat (adipose) tissue and signals satiety to the brain. It inhibits food intake by acting on the hypothalamus. Therefore, leptin suppresses appetite, not stimulates it.
Statement C -Leptin receptors are located in hypothalamus - Correct
Leptin receptors are prominently located in the arcuate nucleus of the hypothalamus, which plays a central role in energy homeostasis. It helps regulate hunger and energy expenditure.
Statement D - Ghrelin produced in the stomach inhibits food intake - Incorrect
Ghrelin is the only known peripheral hormone that stimulates hunger. It is secreted from the stomach, particularly before meals, and promotes food intake.
Statement E - Leptin also stimulates the metabolic rate - Correct
Leptin not only suppresses appetite but also increases energy expenditure by stimulating metabolic rate through action on the hypothalamus.
Statement F - Ghrelin increases secretion of Neuropeptide Y (NPY) - Correct
Ghrelin stimulates the release of Neuropeptide Y, a potent orexigenic (appetite-stimulating) peptide in the hypothalamus. This promotes increased food intake.
Correct Statements: C, E, and F
So, the correct answer is option d - C , E and F.
