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    ​Sturtevant introduced the concept of recombination frequency-based genetic maps. Since genetic distances between genes may be underestimated due to t
    Question

    Sturtevant introduced the concept of recombination frequency-based genetic maps. Since genetic distances between genes may be underestimated due to the occurrence of double crossovers, other mapping functions were developed to provide more accurate estimates. Haldane's mapping function assumes no interference between crossovers, while Kosambi's mapping function accounts for interference. The following graph presents the relationship between recombination frequency and map distance (cM) as proposed by Sturtevant and after corrections using either Haldane’s or Kosambi’s mapping functions.

    The following statements were made about genetic maps.
    A. Line I in the above plot represents the relationship between recombination frequency and map distance based on Kosambi function.
    B. The chance of underestimation of map distance increases with an increase in recombination frequency.
    C. Genetic mapping proposed by Sturtevant assumes complete interference.

    Which one of the following options correctly identifies each statement as True (T) or False (F) from A to C, respectively?

    A.

    T, T, T

    B.

    T, T, F

    C.

    T, F, T

    D.

    F, T, T

    Correct option is D

    A. Line I in the above plot represents relationship based on Kosambi function.
     False. Line I shows the least correction, which corresponds to Sturtevant’s original mapping (no correction). Kosambi’s function (moderate correction) is Line II.

    B. The chance of underestimation of map distance increases with increase in recombination frequency.
    True. At higher recombination frequencies, double crossovers are more likely, and simple mapping (like Sturtevant’s) underestimates the true distance.

    C. Genetic mapping proposed by Sturtevant assumes complete interference.
    True. Sturtevant assumed no double crossovers, implying complete interference (i.e., one crossover prevents another nearby).

    So, the correct option (d)  F, T, T.

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