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    ​Iron-sulphur clusters [Fe-S] are the key prosthetic groups that carry electrons in all of the below EXCEPT:​
    Question

    Iron-sulphur clusters [Fe-S] are the key prosthetic groups that carry electrons in all of the below EXCEPT:

    A.

    NADH - CoQ reductase

    B.

    Succinate - CoQ reductase

    C.

    Cytochrome C oxidase

    D.

    CoQH2 - Cytochrome C reductase

    Correct option is C

    Explanation-

    Iron-sulfur clusters are cofactors found in many enzymes involved in electron transport. They help transfer electrons due to their ability to shift oxidation states.
    Option a -  NADH – CoQ reductase (Complex I)
    It contains Fe–S clusters. It transfers electrons from NADH to CoQ. Fe–S clusters are central here.
    Option b - Succinate – CoQ reductase (Complex II)
    It contains Fe–S clusters. It transfers electrons from succinate (via FADH2) to CoQ. It has multiple Fe–S centers.
    Option c -  Cytochrome C oxidase (Complex IV)
    It does NOT contain Fe–S clusters. It uses cytochrome a and a3 and copper ions (CuA and CuB) to transfer electrons to oxygen. There is no iron-sulfur groups here.
    Option d - CoQH₂ – Cytochrome C reductase (Complex III)
    It contains Fe–S clusters. It is also called cytochrome bc1 complex. It uses Rieske Fe–S protein to transfer electrons.

    So, the correct answer is option c - Cytochrome C oxidase

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