In case of poisoning by organophosphate insecticides the antidote used is:

Correct option is D

Organophosphate (OP) poisoning occurs due to inhibition of acetylcholinesterase (AChE) enzyme, resulting in accumulation of acetylcholine at synapses and neuromuscular junctions. This leads to overstimulation of cholinergic receptors, causing symptoms like:
· Salivation
· Lacrimation
· Urination
· Diarrhea
· Bradycardia
· Muscle twitching, convulsions
Antidote:
· Atropine is the primary antidote used for OP poisoning.
· It is a muscarinic antagonist that blocks acetylcholine at muscarinic receptors, thereby reducing secretions and countering the parasympathetic effects of acetylcholine overload.
· It does not reactivate AChE but is vital in managing symptoms.
Other supportive antidote (used with atropine but not as a substitute):
· Pralidoxime (2-PAM): Reactivates AChE if given early.
· Diazepam: Used to control convulsions but not an antidote.
�� Therefore, the correct answer is (d) Atropine.