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    ​Which one of the following tissues normally  produce ghrelin that stimulates food intake?​
    Question

    Which one of the following tissues normally  produce ghrelin that stimulates food intake?

    A.

    Stomach

    B.

    Pancreas

    C.

    Adrenal

    D.

    Liver

    Correct option is A

    Explanation-

    ​Ghrelin is a peptide hormone that stimulates appetite (also known as the “hunger hormone”). It is primarily produced by specialized cells in the lining of the stomach, particularly the P/D1 cells in the fundus (upper part of the stomach). While small amounts may be produced in the pancreas , the stomach is the main source.

    Incorrect options - 

    Option b -  Pancreas
    The pancreas can produce very small amounts of ghrelin, but it is not the main source. Its role in ghrelin production is minor and not significant in terms of stimulating hunger. Main pancreatic functions involve insulin, glucagon, somatostatin, and pancreatic enzymes.
    Option c - Adrenal glands
    The adrenal glands do not produce ghrelin. Their function is to produce steroid hormones (like cortisol, aldosterone) and catecholamines (like adrenaline and noradrenaline). They play a role in stress response, not hunger regulation.
    Option d -  Liver
    The liver does not normally produce ghrelin. It plays a central role in metabolism, detoxification, and nutrient storage. While the liver may respond to ghrelin’s effects, it does not secrete it under normal physiological conditions.

    Final answer - Option a - Stomach

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