Correct option is A
The correct answer is (a).
Non-classical cadherins such as Fat and Flamingo play crucial roles in regulating epithelial growth and cell polarity. Fat is involved in regulating growth and maintaining the size of tissues by controlling the size of cells during development, while Flamingo is involved in establishing and maintaining cell polarity during developmental processes. These cadherins differ from classical cadherins like E-cadherin, which are mainly involved in cell adhesion.
Incorrect options-
Option (b) is incorrect because anti-N cadherin antibody does not prevent compaction in early mouse embryos. Compaction is primarily mediated by E-cadherin, not N-cadherin.
Option (c) is incorrect because P-cadherins are classical cadherins with transmembrane domains, not GPI-anchored proteins. GPI anchors are characteristic of some non-classical cadherins, but not P-cadherins.
Option (d) is incorrect as loss of desmoglein causes skin blistering due to decreased keratinocyte adhesion, not increased. Desmoglein is a component of desmosomes, and its loss disrupts cell-cell adhesion leading to blister formation.
