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    ​Some cellular and extracellular proteins are enlisted in List I and their typical characteristics are enlisted in List II​​List I​​​List II​​A. Nidog
    Question

    Some cellular and extracellular proteins are enlisted in List I and their typical characteristics are enlisted in List II

    List I​​
    List II
    A. Nidogen​​
    I. In human genome, one gene of this protein is present but many different isoforms are there due to alternative splicing​​
    B. Fibronectin
    II. An intermediate filament protein that is typically expressed in epithelial and mesenchymal cells
    C. Integrin
    III. One of the principal structural proteins of basal laminae
    D. Vimentin
    IV. Heterodimer of α and β subunit and binds to extracellular matrix proteins

    Which one of the following is the most appropriate match?

    A.

    A-I, B-II, C-III, D-IV

    B.

    A-II, B-III, C-IV, D-I

    C.

    A-III, B-I, C-IV, D-II

    D.

    A-II, B-IV, C-I, D-III

    Correct option is C

    Explanation-

    ​A. Nidogen → III. One of the principal structural proteins of basal laminae.
    Nidogen (also called entactin) is a key component of the basement membrane, playing a role in linking laminin and type IV collagen—important structural elements of basal lamina.

    B. Fibronectin → I. In human genome, one gene of this protein is present but many different isoforms are there due to alternative splicing.
    Fibronectin is encoded by a single gene but has many isoforms due to alternative splicing.

    C. Integrin → IV. Heterodimer of α and β subunit and binds to extracellular matrix proteins.
    Integrins are transmembrane receptors made of α and β subunits that connect the ECM to the cytoskeleton.

    D. Vimentin → II. An intermediate filament protein that is typically expressed in epithelial and mesenchymal cells.
    Vimentin is a type III intermediate filament, widely expressed in mesenchymal cells, and also in some epithelial types under specific conditions.

    Final Correct Match :
    A – III , B – I , C – IV , D – II 
    So, Option c is  correct.

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