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    ​Which one of the following proteins is NOT related to the extracellular matrix?​
    Question

    Which one of the following proteins is NOT related to the extracellular matrix?

    A.

    Cadherin

    B.

    Vitronectin

    C.

    Lamin

    D.

    Selectin

    Correct option is C

    Explanation-

    The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, and polysaccharides secreted by cells that provides structural and biochemical support to surrounding cells.
    Option C - Lamin
    Function: Nuclear protein – forms the nuclear lamina under the inner nuclear membrane.
    Location: Inside the nucleus.
    It is not part of ECM, but part of nuclear architecture.

    Incorrect options- 
    Option A - Cadherin
    Function: Cell-to-cell adhesion protein (calcium-dependent).
    Location: Found on the plasma membrane between adjacent cells.
    However, still associated with cell-cell adhesion more than ECM scaffolding.
    Option B - Vitronectin
    Function: ECM glycoprotein that promotes cell adhesion, migration, and wound healing.
    Location: Found in the ECM and plasma.
    Related to ECM - It is an established ECM protein.
    Option D - Selectin
    Function: Cell adhesion molecule that binds carbohydrates.
    Location: On leukocytes, platelets, and endothelial cells.
    It plays a role in cell-ECM and cell-cell adhesion during inflammation and immune response.

    Since lamin is the only one among these options which is not directly related to ECM that makes it a correct answer.

    So, the correct answer is option C- Lamin

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