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​Which one of the following proteins is NOT related to the extracellular matrix?​
Question

Which one of the following proteins is NOT related to the extracellular matrix?

A.

Cadherin

B.

Vitronectin

C.

Lamin

D.

Selectin

Correct option is C

Explanation-

The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, and polysaccharides secreted by cells that provides structural and biochemical support to surrounding cells.
Option C - Lamin
Function: Nuclear protein – forms the nuclear lamina under the inner nuclear membrane.
Location: Inside the nucleus.
It is not part of ECM, but part of nuclear architecture.

Incorrect options- 
Option A - Cadherin
Function: Cell-to-cell adhesion protein (calcium-dependent).
Location: Found on the plasma membrane between adjacent cells.
However, still associated with cell-cell adhesion more than ECM scaffolding.
Option B - Vitronectin
Function: ECM glycoprotein that promotes cell adhesion, migration, and wound healing.
Location: Found in the ECM and plasma.
Related to ECM - It is an established ECM protein.
Option D - Selectin
Function: Cell adhesion molecule that binds carbohydrates.
Location: On leukocytes, platelets, and endothelial cells.
It plays a role in cell-ECM and cell-cell adhesion during inflammation and immune response.

Since lamin is the only one among these options which is not directly related to ECM that makes it a correct answer.

So, the correct answer is option C- Lamin

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