Correct option is D
Let’s evaluate each statement about cadherins and their role in cell junctions:
A. Cadherins are calcium-dependent adhesion molecules that mediate cell to cell adhesion by forming homophilic interactions.
This is correct. Cadherins are indeed calcium-dependent proteins that facilitate cell-to-cell adhesion through homophilic (same-type) interactions.
B. Cadherins function in tight junctions, sealing the space between adjacent cells.
This is incorrect. Tight junctions are primarily mediated by proteins like occludins and claudins, not cadherins. Cadherins are more associated with adherens junctions and desmosomes.
C. N-cadherins are primarily found in epithelial cells and mediate adhesion to the basal lamina.
This is incorrect. N-cadherins are typically found in neural tissues and mesenchymal cells, not primarily in epithelial cells (which are more associated with E-cadherins). Additionally, adhesion to the basal lamina is mediated by integrins, not cadherins.
D. Cadherins are involved in the formation of focal adhesions, linking the cell cytoskeleton to the ECM.
This is incorrect. Focal adhesions are formed by integrins, which connect the cytoskeleton to the extracellular matrix (ECM). Cadherins link the cytoskeleton to other cells, not the ECM.
E. Cadherins interact with the actin cytoskeleton through associated proteins like catenins.
This is correct. Cadherins, particularly in adherens junctions, interact with the actin cytoskeleton via catenin proteins (like alpha- and beta-catenin).
Correct Statements:
A and E are correct.
