Correct option is B
The correct answer is (b).
Insulin signaling inhibits the activity of FoxO (Forkhead box O) transcription factors. FoxO proteins play a crucial role in protecting cells from stress and promoting cellular maintenance and survival. When FoxO is active, it helps in regulating genes involved in cell cycle arrest, apoptosis resistance, and DNA repair, which are important in preventing premature senescence. However, when insulin signaling is active, FoxO is inhibited, leading to a reduced ability to protect cells from stress and senescence. Thus, FoxO functions to protect cells from senescence, and insulin signaling inhibits its activity.
Incorrect options-
Option (a): Insulin signaling does not activate FoxO; it inhibits it. Also, FoxO generally protects against senescence rather than promoting it.
Option (c): Insulin signaling activates FoxO is incorrect; insulin signaling inhibits FoxO activity.
Option (d): Insulin signaling inhibits FoxO is correct, but FoxO does not promote senescence; it protects cells from senescence, making this option partly incorrect.
