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    Which of the following is not a correct statement about Huntington’s disease, an autosomal linked dominant trait in human beings?
    Question

    Which of the following is not a correct statement about Huntington’s disease, an autosomal linked dominant trait in human beings?

    A.

    It can affect both male and female.

    B.

    Heterozygous individual would also exhibit the trait.

    C.

    For a person to be homozygous for Huntington’s gene, only one of his/her parents must be suffering from the disease.

    D.

    If inherited, it will be expressed in all the generations in a pedigree.

    Correct option is C

    Correct Answer: (c)
    Explanation:
    A person cannot be homozygous for Huntington’s if only one parent is affected, since both alleles must carry the mutant gene.
    Hence, (c) is the incorrect statement.
    Information Booster:
    Huntington’s disease is autosomal dominant.
    Caused by CAG repeat expansion in the HTT gene on chromosome 4.
    Symptoms: involuntary movements, memory loss, psychiatric changes.
    Onset generally between ages 30–50.
    Heterozygotes express the disorder; homozygotes are rare and more severely affected.
    Additional Information (Incorrect Options):
    (a) True — both sexes affected equally.
    (b) True — one mutant allele is enough.
    (d) True — dominant traits appear in every generation.

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