Correct option is C
Key Points from the Experiment:
The goal of the experiment is to determine how Bcl2 and Myc genes interact to cause B-cell lymphomas.
The survival of mice was monitored under different experimental conditions:
Bcl2 alone
Myc alone
Myc + Bcl2 combined
The graphs provided show the number of surviving mice over time (days). A rapid drop in the number of surviving mice indicates a higher rate of lymphoma development.
Analyzing the Figures:
Figure 1:
Bcl2 alone does not cause a rapid decrease in survival, suggesting Bcl2 alone doesn't induce lymphoma.
Myc + Bcl2 shows a dramatic drop in survival very quickly, suggesting the combination leads to faster lymphoma development.
This combination indicates synergy between Myc and Bcl2, leading to lymphoma at a faster rate. However, it might not perfectly match the expected outcome of how lymphoma develops over time.
Figure 2:
Bcl2 alone has a relatively slow decline in survival.
Myc alone also causes lymphoma, but at a slower rate compared to the combination of Myc and Bcl2.
The Myc + Bcl2 combination leads to rapid death, but the data does not represent the expected results fully since Myc alone should cause faster lymphoma development compared to Bcl2 alone.
Figure 3:
Bcl2 alone does not significantly affect survival (it is a survival gene, so it might delay cell death).
Myc alone leads to a significant drop in survival, suggesting Myc alone can cause lymphoma in the mice over time.
The combination of Myc + Bcl2 results in an even faster decrease in survival, suggesting Myc + Bcl2 causes lymphoma at the most rapid rate, which is what we expect with this genetic synergy.
Figure 4:
Bcl2 alone has little effect on survival.
Myc alone shows a more rapid reduction in survival, but the combination of Myc + Bcl2 is expected to show the fastest reduction in survival, which is not as rapid as in Figure 3.
Conclusion:
Option 3 (Figure 3) correctly represents the combination where Myc + Bcl2 leads to the most rapid lymphoma development, as shown by the sharp decline in the number of surviving mice. Myc alone also causes lymphoma, but the addition of Bcl2 accelerates the process.
