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​Which of the following is/are associated with the presentation of endogenous antigens by Class I MHC molecule by an Antigen Presenting Cell (APC), gi
Question

Which of the following is/are associated with the presentation of endogenous antigens by Class I MHC molecule by an Antigen Presenting Cell (APC), given the condition that there is no cross-presentation of antigens by the APC?

A.

TAP1 and TAP2 proteins only

B.

Invariant chain (Ii)

C.

Proteosome-like subunits LMP2 and LMP7 only

D.

TAP1, TAP2 proteins and proteosome-like subunits LMP2, LMP7

Correct option is D

Explanation-

This pathway presents endogenous antigens (from within the cell, e.g., viral proteins) to CD8+ T cells.
Key components involved:
              1.   Proteasome (LMP2, LMP7): Degrades cytosolic proteins into peptides.
              2.   TAP1 & TAP2: Transport peptides from cytosol into the endoplasmic reticulum.
              3.   Invariant chain (Ii): NOT involved in MHC-I. It is specific to MHC class II presentation.
Options - 
Option a : TAP1 and TAP2 proteins only
Partially correct (TAPs are essential), but missing proteasome subunits 
Option b : Invariant chain (Ii) 
Invariant chain is part of MHC class II presentation. This is incorrect
Option c : Proteasome-like subunits LMP2 and LMP7 only
Partially correct, but lacks TAP1/TAP2, which are essential for peptide transport 
Option d : TAP1, TAP2 proteins and proteasome-like subunits LMP2, LMP7
Correct. This includes all key components of the MHC-I antigen processing pathway.

Final Answer: Option d  is correct.

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