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    ​Which of the following is/are associated with the presentation of endogenous antigens by Class I MHC molecule by an Antigen Presenting Cell (APC), gi
    Question

    Which of the following is/are associated with the presentation of endogenous antigens by Class I MHC molecule by an Antigen Presenting Cell (APC), given the condition that there is no cross-presentation of antigens by the APC?

    A.

    TAP1 and TAP2 proteins only

    B.

    Invariant chain (Ii)

    C.

    Proteosome-like subunits LMP2 and LMP7 only

    D.

    TAP1, TAP2 proteins and proteosome-like subunits LMP2, LMP7

    Correct option is D

    Explanation-

    This pathway presents endogenous antigens (from within the cell, e.g., viral proteins) to CD8+ T cells.
    Key components involved:
                  1.   Proteasome (LMP2, LMP7): Degrades cytosolic proteins into peptides.
                  2.   TAP1 & TAP2: Transport peptides from cytosol into the endoplasmic reticulum.
                  3.   Invariant chain (Ii): NOT involved in MHC-I. It is specific to MHC class II presentation.
    Options - 
    Option a : TAP1 and TAP2 proteins only
    Partially correct (TAPs are essential), but missing proteasome subunits 
    Option b : Invariant chain (Ii) 
    Invariant chain is part of MHC class II presentation. This is incorrect
    Option c : Proteasome-like subunits LMP2 and LMP7 only
    Partially correct, but lacks TAP1/TAP2, which are essential for peptide transport 
    Option d : TAP1, TAP2 proteins and proteasome-like subunits LMP2, LMP7
    Correct. This includes all key components of the MHC-I antigen processing pathway.

    Final Answer: Option d  is correct.

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