Correct option is A
Explanation-
Breast Cancer Stem Cells Marker Profile:
The typical immunophenotype for breast cancer stem cells is CD44⁺ / CD24⁻. This means high expression of CD44 and low or no expression of CD24
X-axis (FITC – anti-CD44) → CD44 expression
Y-axis (PE – anti-CD24) → CD24 expression
Quadrants:
Lower-right quadrant: CD44⁺ / CD24⁻ → CSC signature
Upper-right: CD44⁺ / CD24⁺
Upper-left: CD44⁻ / CD24⁺
Lower-left: CD44⁻ / CD24⁻
Analyzing the Plots:
Plot A: Most cells in lower-left → CD44⁻ / CD24⁻ → Not CSCs
Plot B: Most cells in lower-right → CD44⁺ / CD24⁻ → Cancer Stem Cell–like population
Plot C: Sparse or background-like → Possibly fibroblasts (negative for both)
Plot D: Many cells in upper-right quadrant → CD44⁺ / CD24⁺ → Double positives (non-stem, or possibly dead cells)
Final Answer:
Option a - B represents a plot that denotes a high percentage of cancer stem cells in the breast cancer cells.
