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​Match the columns:​​Which one of the following options represents all correct matches between Column X and Column Y?​
Question

Match the columns:

Which one of the following options represents all correct matches between Column X and Column Y?

A.

A-I, B-II, C-III, D-IV

B.

A-IV, B-I, C-II, D-III

C.

A-IV, B-II, C-III, D-I

D.

A-II, B-IV, C-III, D-I

Correct option is C

To determine the correct matches between Column X (E. coli genes involved in replication) and Column Y (functional eukaryotic orthologues), let's analyze each pair based on their roles in DNA replication:

A. DnaB: In E. coli, DnaB is a helicase that unwinds DNA during replication. Its eukaryotic orthologue is the MCM complex (Mini-Chromosome Maintenance complex), which also acts as a helicase. So, A matches with iv.
B. DnaC: In E. coli, DnaC helps load DnaB onto the DNA. In eukaryotes, this role is performed by cdc6, which assists in loading the MCM complex. So, B matches with ii.
C. β clamp: In E. coli, the β clamp (part of DNA polymerase III) is a sliding clamp that tethers the polymerase to the DNA for processivity. Its eukaryotic orthologue is PCNA (Proliferating Cell Nuclear Antigen), which serves the same function. So, C matches with iii.
D. DnaG: In E. coli, DnaG is a primase that synthesizes RNA primers for DNA replication. In eukaryotes, this role is performed by Pola/primase (DNA polymerase α/primase complex), which synthesizes RNA primers. So, D matches with i.

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