Given below are the blood clotting factors in column X and their names in column Y.

Column X (Blood Clotting Factors)	Column Y (Names of Factors)
a. XII	i. Fitzgerald factor
b. HMWK	ii. Laki – Lorand factor
c. Pre-Ka	iii. Stuart – Prower factor
d. X	iv. Fletcher factor

Which of the following combinations correctly matches the factor with its name?

Correct option is C

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1. Factor XII (Hageman factor) → Laki-Lorand factor

   • Correct Match: a - ii
   • Factor XII plays a role in initiating the intrinsic pathway of coagulation.

2. HMWK (High-Molecular-Weight Kininogen) → Fitzgerald factor

   • Correct Match: b - i
   • HMWK acts as a cofactor in the contact activation pathway.

3. Pre-Ka (Prekallikrein) → Fletcher factor

   • Correct Match: c - iv
   • Prekallikrein is a precursor of kallikrein, which activates Factor XII.

4. Factor X → Stuart-Prower factor

   • Correct Match: d - iii
   • Factor X is crucial in converting prothrombin to thrombin in the coagulation cascade.

Since option 3 (a-ii, b-i, c-iv, d-iii) correctly matches the factors to their names, it is the correct answer.

Information Booster:

1. Factor XII (Hageman Factor):

   • It is involved in the intrinsic coagulation pathway and is activated by contact with negatively charged surfaces.

2. High-Molecular-Weight Kininogen (HMWK) – Fitzgerald Factor:

   • Acts as a cofactor for the activation of Factor XII and prekallikrein.

3. Prekallikrein (Fletcher Factor):

   • A serine protease precursor that is converted into kallikrein, playing a role in inflammation and coagulation.

4. Factor X (Stuart-Prower Factor):

   • A key enzyme in the coagulation cascade, responsible for the conversion of prothrombin to thrombin in the common pathway.