Correct option is B
Explanation-
Heme biosynthesis occurs in immature erythroid cells (not mature ones) and involves multiple enzymatic steps. The first step is the condensation of succinyl-CoA and glycine, catalyzed by the enzyme δ-aminolevulinate synthase (ALAS).
Statement A - It is synthesized in mature erythrocytes.
Incorrect
Heme synthesis does not occur in mature erythrocytes, as they lack mitochondria and a nucleus, which are essential for heme biosynthesis. It takes place in immature erythroid precursors in the bone marrow.
Statement B - It is synthesized by the condensation of succinyl-CoA and glycine.
Correct
This is the first step of heme synthesis, forming δ-aminolevulinic acid (ALA). This reaction happens in the mitochondria.
Statement C - It is synthesized by the condensation of acetyl-CoA and glycine.
Incorrect
Acetyl-CoA is not involved in heme synthesis. Succinyl-CoA is the correct molecule that condenses with glycine. So this statement is biochemically incorrect.
Statement D - Its synthesis is catalyzed by δ-aminolevulinate synthase.
Correct
This is the correct enzyme for the condensation of succinyl-CoA and glycine into ALA, the first step in heme synthesis. So this statement is true.
Incorrect statement - A and C
So, correct option is b - A and C
