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Which one of the following synaptic vesicles (as observed under transmission electron microscope) contains catecholamines?
Question

Which one of the following synaptic vesicles (as observed under transmission electron microscope) contains catecholamines?

A.

Small, round shaped and clear

B.

Small, round shaped and dense core

C.

Large dense core

D.

Small, flattened and clear

Correct option is B

The correct answer is indeed option (b): Small, round shaped and dense core. This type of vesicle is associated with the storage of catecholamines such as dopamine, norepinephrine, and epinephrine. These neurotransmitters are stored in small, round vesicles that contain a dense core, which can be seen under an electron microscope.

Let’s go over the reasoning:

  • Catecholamines are small, water-soluble neurotransmitters synthesized in the adrenergic neurons and dopaminergic neurons. They are stored in vesicles, which are typically small and round with a dense core.

  • Option (a), the small, round shaped and clear vesicles, typically contain amino acid neurotransmitters like glutamate and GABA, not catecholamines. These vesicles appear clear because they do not have a dense core.

  • Option (c), large dense core vesicles, are typically associated with the storage of neuropeptides, such as substance P or oxytocin, not catecholamines.

  • Option (d), small, flattened and clear, does not describe typical vesicles for catecholamines or other major neurotransmitters.

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