Blood hemostasis is the interplay of several intrinsic and extrinsic factors. Deficiency of some of the blood clotting factors and their clinical manifestations are listed below.

Factors	Manifestations
A. V	i. Hageman trait
B. VII	ii. Hypoconvertemia
C. IX	iii. Hemophilia B
D. XII	iv. Parahemophilia

Which one of the following options represents all correct matches?

Correct option is B

Correct Answer: (2) A-(iv), B-(ii), C-(iii), D-(i)

Explanation – Matching Clotting Factors to Clinical Manifestations:

Let's match the clotting factors (also called coagulation factors) to the clinical conditions caused by their deficiencies:

A. Factor V → (iv) Parahemophilia

• Parahemophilia is caused by Factor V deficiency, a rare autosomal recessive disorder.

• It leads to mild to moderate bleeding tendency.

A → iv

B. Factor VII → (ii) Hypoconvertinemia

• Deficiency of Factor VII causes Hypoproconvertinemia, also known as Hypoconvertinemia.

• It’s a rare bleeding disorder affecting the extrinsic pathway.

B → ii

C. Factor IX → (iii) Hemophilia B

• Hemophilia B (also called Christmas disease) is caused by Factor IX deficiency.

• It’s an X-linked recessive disorder, mostly affecting males.

C → iii

D. Factor XII → (i) Hageman trait

• Factor XII deficiency is also known as the Hageman trait.

• Interestingly, although Factor XII is part of the intrinsic pathway, its deficiency does not typically cause bleeding, but is detected due to prolonged aPTT in lab tests.

D → i