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    ​Which one of the following is NOT a true effect of aldosterone on the principal cells of distal tubule and the collecting duct to increase the reabso
    Question

    Which one of the following is NOT a true effect of aldosterone on the principal cells of distal tubule and the collecting duct to increase the reabsorption of Na⁺?

    A.

    Stimulation of CAP1 levels

    B.

    Decrease in the serum and glucocorticoid-regulated kinase 1 (Sgk1) levels

    C.

    Increase in the expression of ENaC in the apical membrane

    D.

    Increase in the amount of Na⁺, K⁺-ATPase in the basolateral membrane

    Correct option is B

    The correct answer is (b).

    Aldosterone increases, not decreases, the expression of serum and glucocorticoid-regulated kinase 1 (Sgk1). Sgk1 plays a role in the regulation of sodium and potassium transport by enhancing the activity of channels and transporters involved in sodium reabsorption.

    Incorrect option-

    Option (a) is true; CAP1 is stimulated by aldosterone to regulate sodium transport.

    Option (c) is true; aldosterone increases ENaC expression in the apical membrane to enhance sodium reabsorption.

    Option (d) is true; aldosterone increases Na+, K+-ATPase in the basolateral membrane to facilitate sodium extrusion into the blood.

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