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    ​Which one of the following is likely to enter a pure phospholipid bilayer?​
    Question

    Which one of the following is likely to enter a pure phospholipid bilayer?

    A.

    CO₂ and Diethyl urea

    B.

    Water and Glucose

    C.

    Lysine and Ethanol

    D.

    Urea and Chloride ions

    Correct option is A

    A phospholipid bilayer, which forms the core structure of cell membranes, is a hydrophobic structure that allows the passage of small, non-polar molecules and some small polar molecules that are lipophilic (fat-soluble).

    • CO₂ (carbon dioxide) is a non-polar molecule and can diffuse easily across the bilayer.

    • Diethyl urea is a small polar molecule, but due to its low polarity and small size, it can pass through the hydrophobic core of the phospholipid bilayer, though with slower diffusion compared to non-polar molecules.

    Information Booster:

    • CO₂ is a non-polar molecule and easily crosses the phospholipid bilayer through simple diffusion.

    • Diethyl urea, despite being polar, is small enough to cross the hydrophobic core of the membrane, making it permeable, although less so than CO₂.

    • Phospholipid bilayers are semipermeable and allow small, non-polar molecules to pass through more readily, while polar and charged molecules require transport mechanisms.

    • Molecules like water and glucose are polar and typically require specialized transport proteins to cross the membrane effectively.

    • Lysine, an amino acid, is highly charged and would have difficulty crossing the bilayer without the assistance of transporters.

    • Ethanol, while small and polar, can pass through the bilayer due to its amphipathic nature, but it does so less efficiently compared to non-polar molecules.

    • Urea is small and polar, and while it can cross the bilayer to some extent, it still has some difficulty due to its polarity.

    • Chloride ions are highly charged and cannot diffuse through the hydrophobic core of the membrane without transport proteins.

    Additional Information:

    • (b) Water and Glucose: Water can pass through the bilayer, but glucose is too large and polar to diffuse through unaided.

    • (c) Lysine and Ethanol: Lysine is too charged to pass easily, and ethanol, though small and polar, can diffuse, but less easily than non-polar molecules like CO₂.

    • (d) Urea and Chloride ions: Both are polar and charged, making it difficult for them to pass through the bilayer without the aid of specific transporters.

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