Correct option is B
Explanation-
Phosphofructokinase (PFK) is a key regulatory enzyme in glycolysis. Its activity is tightly controlled through allosteric regulation:
ATP acts as an allosteric inhibitor of PFK (when ATP levels are high, PFK activity is decreased to slow glycolysis). AMP/ADP act as activators, promoting glycolysis when energy is low.
The mutation causes loss of allosteric inhibition by ATP, but does not affect the catalytic site. That means PFK still works, but it no longer "listens" to ATP’s signal to slow down. Without ATP inhibition, PFK will continue to function even when ATP is abundant.
This leads to increased activity of PFK, because the enzyme is no longer being turned off by high ATP levels.
So, the correct answer is option b - Increase in the activity of PFK
Incorrect Options-
Option a- Decrease in PFK activity Opposite of what happens— PFK is more active, not less.
Option c - Decrease in ADP production Misleading— PFK uses ATP and does not directly generate ADP; not relevant here.
Option d- Increase in ATP production Indirectly may happen due to increased glycolysis, but the direct effect is on PFK activity, not ATP levels.
