Correct option is D
The statement that Xer recombinase-mediated monomerization of chromosomal dimers, the interaction of FtsK with XerCD activates XerC and initiates the recombination process is NOT true. While the interaction between FtsK and XerCD does indeed play a crucial role in the monomerization of chromosomal dimers, it is actually the XerD protein that activates XerC and mediates the recombination process, not XerC itself. The role of XerC is to catalyze the recombination process once activated by XerD.
Information Booster
- Xer recombinase system is essential for resolving chromosomal dimers that occur during DNA replication in bacteria.
- The FtsK protein is involved in DNA translocation and facilitates the interaction between XerCD and the recombination sites.
- The recombination process in the Xer system is activated by XerD, which then activates XerC to catalyze the recombination.
- The role of XerC is to perform the recombination event itself, not to initiate the process.
- The lambda integrase (λ integrase) can mediate the integration of the λ genome into the host genome independently of accessory proteins.
- Hin invertase works in DNA inversion in bacteria and is regulated by protein-DNA interactions at the 60 bp enhancer sequence.
Additional Information
- Statement (a) is true because Cre recombinase facilitates the circularization of the P1 phage genome during infection through the recombination of loxP sites.
- Statement (b) is true because the λ integrase can mediate the integration of the λ genome into the host genome by recognizing attB and attP sites, even though accessory proteins may improve the efficiency.
- Statement (c) is true as Hin invertase catalyzes site-specific recombination events for DNA inversion and is regulated by specific protein-DNA interactions, including those at a 60 bp enhancer sequence.
