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    ​What is the nature of India's indigenous COVID-19 vaccine?​
    Question

    What is the nature of India's indigenous COVID-19 vaccine?

    A.

    It is an mRNA vaccine (for expression of viral spike protein)

    B.

    It is a preparation of inactivated whole virus

    C.

    It is a preparation of attenuated SARSCoV2 virus

    D.

    It is a recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike (S) glycoprotein

    Correct option is B

    Explanation-

    India's first indigenous COVID-19 vaccine is Covaxin, developed by Bharat Biotech in collaboration with the Indian Council of Medical Research (ICMR). Covaxin is a whole virion inactivated vaccine, meaning - It contains SARS-CoV-2 viruses that have been killed (inactivated), so they cannot replicate or cause disease, but still elicit an immune response. It uses a well-established platform used in many traditional vaccines.

    Incorrect Options -
    Option a - mRNA vaccine – This applies to vaccines like Pfizer-BioNTech and Moderna, not Covaxin.
    Option c - Attenuated virus – Involves a live but weakened virus, which Covaxin is not. India hasn’t used attenuated COVID vaccines widely.
    Option d - Recombinant adenovirus vector vaccine – This refers to Covishield (Oxford-AstraZeneca vaccine), which is not indigenous (though manufactured in India by Serum Institute).

    Correct Option: Option b -  It is a preparation of inactivated whole virus

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