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​The principal product of fat digestion by pancreatic lipase is the free fatty acids (FFAs) and which one of the following?​
Question

The principal product of fat digestion by pancreatic lipase is the free fatty acids (FFAs) and which one of the following?

A.

3- monoacylglycerols

B.

2- monoacylglycerols

C.

1- monoacylglycerol

D.

1, 3- diacylglycerols

Correct option is B

Explanation-

Pancreatic lipase is the main enzyme responsible for breaking down dietary triglycerides (the most common form of fat in food). A triglyceride consists of one glycerol backbone and three fatty acids (attached at the 1, 2, and 3 positions).
Action of pancreatic lipase:
                 1.  It hydrolyzes the ester bonds at positions 1 and 3 of triglycerides.
                 2.  This releases two free fatty acids (FFAs) and one 2-monoacylglycerol (fatty acid remaining at the 2-position)
Correct Answer: Option b – 2-monoacylglycerols
2-monoacylglycerol is the primary intermediate (along with FFAs) formed in the small intestine during fat digestion. This molecule is more stable and readily absorbed by intestinal cells.

Incorrect Options -
Option a - 3-monoacylglycerols – Rarely formed; pancreatic lipase does not leave fatty acid at position 3.
Option c - 1-monoacylglycerol – Not the main product; position 1 is usually hydrolyzed.
Option d -1,3-diacylglycerols – Intermediate form but not a final product after complete digestion by pancreatic lipase.

Final Answer: Option b – 2-monoacylglycerols

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