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    The dark current in retina is due to:
    Question

    The dark current in retina is due to:

    A.

    Closing of Na⁺ channels in the outer segment of photoreceptors

    B.

    Opening of K⁺ channels in the inner segment of photoreceptors

    C.

    Opening of Na⁺ channels in the outer segment of photoreceptors

    D.

    Closing of K⁺ channels in the outer segment of photoreceptors

    Correct option is C

    Explanation-

    In darkness (i.e., absence of light), photoreceptors (rods and cones in the retina) are depolarized due to a continuous inward flow of Na⁺ ions. This is known as the dark current.
    In the outer segment of photoreceptors, Na⁺ channels remain open due to the presence of cGMP (cyclic guanosine monophosphate). This allows a steady flow of Na⁺ (sodium ions) into the cell, which keeps it depolarized. This depolarization leads to the release of neurotransmitters even in the absence of light.
    When light hits photoreceptors:
                           1.  cGMP levels drop.
                           2.  Na⁺ channels close.
                           3.  The cell hyperpolarizes.
                           4.   Neurotransmitter release decreases.
    Incorrect Options:
    Option a - Closing of Na⁺ channels in the outer segment of photoreceptors – This happens in light, not in dark.
    Option b - Opening of K⁺ channels in the inner segment of photoreceptors – This happens normally, but does not cause the dark current.
    Option d - Closing of K⁺ channels in the outer segment of photoreceptors – Irrelevant; K⁺ efflux continues and doesn’t create the inward dark current.

    So, the correct answer is option c - Opening of Na⁺ channels in the outer segment of photoreceptors

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