Correct option is B
Kaposi's sarcoma is associated with Human Herpesvirus-8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV). The condition is more prevalent in individuals with compromised immune systems, such as those with HIV/AIDS. HIV weakens the immune system, allowing HHV-8 to induce tumorigenesis, resulting in vascular tumors characteristic of Kaposi's sarcoma.
Information Booster:
- Kaposi's sarcoma is a vascular tumor linked to HHV-8 infection.
- It is common in HIV-positive individuals due to immune suppression.
- HHV-8 infects endothelial cells, leading to abnormal blood vessel formation.
- The condition presents as purple, reddish-brown skin lesions.
- Antiretroviral therapy reduces the incidence of Kaposi's sarcoma in HIV patients.
Additional Knowledge:
- Epstein-Barr Virus (EBV) (Option a):
EBV is associated with diseases like Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma but is not linked to Kaposi's sarcoma. - HIV and HHV-8 (Option b):
Correct. HHV-8 is the causative agent of Kaposi's sarcoma, and HIV contributes by suppressing the immune system, allowing HHV-8 to trigger tumor formation. - HTLV type 1 (Option c):
Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma but not with Kaposi's sarcoma. - HPV (Option d):
Human papillomavirus (HPV) is associated with cervical, anal, and oropharyngeal cancers but is unrelated to Kaposi's sarcoma.
