Given below is the list of viruses in Column X and their receptors in human host cells in Column Y.

Column X Viruses	Column Y Receptors
A. Influenza A	i. CD21
B. SARS coronavirus	ii. Sialic acid
C. Poliovirus	iii. ACE 2
D. HIV	iv. CD4
E. Epstein-Barr Virus	v. CD155

Which one of the following options gives all correct matches between Column X and Column Y?

Correct option is C

Option 3 is correct answer : A-II;B-III; C-V; D-IV; E-I

Step-by-Step Analysis:

1. Influenza A (A):

   • Influenza A virus uses sialic acid as its receptor. The virus binds to sialic acid on the surface of host cells, particularly epithelial cells in the respiratory tract. This binding is essential for the virus to enter the host cell.

   • Correct pairing: A - ii (Sialic acid).

2. SARS coronavirus (B):

   • SARS-CoV (the virus that causes COVID-19) primarily binds to the ACE2 receptor on host cells. ACE2 is expressed on various cells, including those in the human respiratory tract and other organs. This receptor facilitates the entry of SARS-CoV into human cells.

   • Correct pairing: B - iii (ACE 2).

3. Poliovirus (C):

   • Poliovirus binds to the CD155 receptor (also known as poliovirus receptor, or PVR) on the surface of host cells. This receptor is particularly important for the virus’s ability to infect nerve cells during poliovirus infection.

   • Correct pairing: C - v (CD155).

4. HIV (D):

   • HIV (Human Immunodeficiency Virus) enters host cells through the CD4 receptor on T-helper cells. The interaction between HIV's envelope glycoprotein and CD4 is critical for the virus's entry into the host cell, along with a co-receptor, such as CCR5 or CXCR4.

   • Correct pairing: D - iv (CD4).

5. Epstein-Barr Virus (E):

   • Epstein-Barr Virus (EBV) binds to the CD21 receptor on B-cells. CD21 (also known as CR2) is the primary receptor for EBV, which is involved in various immune responses and plays a role in the entry of EBV into B-cells.

   • Correct pairing: E - i (CD21).