The following statements were made about major histocompatibility complex (MHC) molecules:
A. Multiple MHC-I molecules can be expressed on a single cell.
B. MHC-I molecules exhibit greater diversity than antibodies.
C. MHC-I haplotypes inherited from the mother and father and expressed on a given cell are codominant.
D. All MHC-I molecules on a given cell express the same endogenous peptide.
E. MHC-I molecules are present on platelets.
Which one of the following options represents the combination of all correct statements?

Correct option is B

Correct Answer:
(b) A, C and E
Explanation:
A single cell expresses multiple MHC-I molecules (e.g., HLA-A, HLA-B, HLA-C), so statement A is correct.
MHC-I genes inherited from both parents are codominantly expressed, making statement C correct.
Although platelets are anucleate, they do express MHC-I molecules derived from megakaryocytes, so statement E is also correct.
Information Booster :
· MHC-I molecules present endogenous peptides to CD8⁺ T cells.
· Codominant expression increases peptide presentation diversity at the population level.
· Platelet MHC-I expression has implications in transfusion immunology.
· Antibody diversity arises from somatic recombination, exceeding MHC diversity.
Additional Information (Incorrect Options):
Statement B: Incorrect because antibodies exhibit far greater diversity due to V(D)J recombination and somatic hypermutation.
Statement D: Incorrect since different MHC-I molecules on the same cell can present different endogenous peptides.
Hence, options containing B or D are incorrect.