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A newborn with unconjugated hyperbilirubinemia is started on phototherapy. What bilirubin decline is expected if therapy is effective?
Question

A newborn with unconjugated hyperbilirubinemia is started on phototherapy. What bilirubin decline is expected if therapy is effective?

A.

0.5 mg/dl every 24 hrs

B.

1–2 mg/dl every 4–6 hrs

C.

0.5–1 mg/dl every 12 hrs

D.

3–4 mg/dl every 24 hrs

Correct option is B

Effective phototherapy reduces serum bilirubin by 1–2 mg/dl every 4–6 hrs, preventing kernicterus.
Explanation of options: (a) ✘ 0.5 mg/dl in 24 hrs is too slow, inadequate. (b) ✔ Correct; 1–2 mg/dl drop in 4–6 hrs is therapeutic. (c) ✘ 0.5–1 mg/dl per 12 hrs is suboptimal. (d) ✘ 3–4 mg/dl per day is possible but not the standard indicator.

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