Correct option is B
Explanation-
The filtration slit diaphragm is a specialized structure in the kidney, located between the foot processes (pedicels) of podocytes in the glomerulus. It is crucial for selective permeability in the filtration of blood.
Proteins Present in the Slit Diaphragm:
1. Nephrin – a key structural component of the slit diaphragm.
2. NEPH1 and NEPH2 – also integral membrane proteins, part of the nephrin signaling complex.
These proteins form a complex that maintains the integrity of the glomerular filtration barrier.
Option b - Paxillin is a cytoskeletal protein involved in focal adhesion and actin cytoskeleton organization. It is not a component of the slit diaphragm, and is found in different cellular contexts, such as in cell-matrix adhesion sites, not in podocyte slit diaphragms.
So, the correct answer is option b - Paxillin
