Choose the correct answer from the options given below:

Which of the following neurotoxins are used to produce selective chemical lesions in the study of the brain-behavior relationship?
A. Dopaminesterage
B. Kainic acid
C. 2-deoxyglucose
D. Ibotenic acid
E. 6-Hydroxydopamine

Correct option is D

In neuroscience research, chemical lesions are induced by selective neurotoxins to study brain function and behavior. Among the listed neurotoxins, the correct ones used for selective brain lesions are:

B. Kainic Acid
A powerful excitotoxic neurotoxin that selectively damages glutamatergic neurons.
Used to study epilepsy, neurodegeneration, and excitotoxicity.
Often applied in hippocampal lesion studies to model Alzheimer's disease.

E. 6-Hydroxydopamine (6-OHDA)
A dopaminergic and noradrenergic neurotoxin that selectively destroys dopamine and norepinephrine neurons.
Used in Parkinson’s disease models to selectively damage dopaminergic neurons in the substantia nigra.
Thus, B (Kainic acid) and E (6-OHDA) are the correct answers.

Information Booster:
Permanent lesions (e.g., electrolytic, excitotoxic, neurotoxic) help understand brain damage and recovery.
Temporary lesions (e.g., cryogenic, pharmacological, optogenetic) allow reversible functional studies.
Modern techniques (optogenetics, chemogenetics, TMS) offer precise, non-invasive control over brain function.