Correct option is B
A. Turner's syndrome → III. Ovum containing no X chromosome is fertilized by an X bearing sperm (resulting in XO karyotype)
B. Fragile-X syndrome → IV. The X chromosome is compressed or broken (due to a fragile site on the X chromosome)
C. Down's syndrome → II. An extra 21st chromosome (trisomy 21)
D. Klinefelter syndrome → I. An imbalance in X chromosome where two X from the ovum combine with a Y sperm (resulting in XXY karyotype)