Which of the following is correct about Thalassemia?
(1) It is a sex linked dominant disease
(2) α Thalassemia is controlled by HBA1 and HBA2
(3) β Thalassemia is controlled by a multiple genes
(4) Thalassemia is a qualitative problem
Choose the correct answer from the options given below:

Correct option is A

Thalassemia is also an autosome-linked recessive blood disease transmitted from parents to the offspring when both the partners are unaffected carrier for the gene (or heterozygous). α Thalassemia is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent and it is observed due to mutation or deletion of one or more of the four genes. The more genes affected, the less alpha globin molecules produced. While β Thalassemia is controlled by a single gene HBB on chromosome 11 of each parent and occurs due to mutation of one or both the genes. Thalassemia differs from sickle-cell anaemia in that the former is a quantitative problem of synthesising too few globin molecules while the latter is a qualitative problem of synthesising an incorrectly functioning globin.