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    Which of the following anti-TB drugs are bactericidal?
    Question

    Which of the following anti-TB drugs are bactericidal?

    A.

    Isoniazid and Rifampicin

    B.

    Ethambutol and Pyrazinamide

    C.

    Streptomycin and PAS

    D.

    Clofazimine and Ethionamide

    Correct option is A

    Rifampicin and isoniazid are first-line bactericidal anti-TB drugs, killing actively multiplying bacilli. Ethambutol is bacteriostatic, while pyrazinamide is bactericidal but not paired in standard question.
    Explanation of options: (a) ✔ Correct; INH + Rifampicin are the most potent bactericidal drugs in TB regimen. (b) ✘ Ethambutol is bacteriostatic; pyrazinamide is bactericidal, but not both together. (c) ✘ Streptomycin is bactericidal, PAS is bacteriostatic. (d) ✘ Clofazimine is used in leprosy and Ethionamide is bacteriostatic.

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