Correct option is B
Explanation:
The table below summarizes various hormones (in Column X) and induced cell responses mediated by them via Cyclic AMP (in Column Y).
Hormone (Column X) | Major Response (Column Y) |
(A) Epinephrine | (i) Increasing heart contraction |
(B) Vasopressin | (ii) Progesterone secretion |
(C) Glucagon | (iii) Water resorption |
(D) Luteinizing hormone | (iv) Glycogen breakdown |
(E) Parathyroid hormone | (v) Bone resorption |
Match all correct combinations from the options given below:
Explanation:
The mechanisms of regulation of H⁺ secretion by kidneys in acidosis have been suggested in the following statements:
A. Acidosis inhibits the secretion of cortisol by adrenal cortex
B. The transcription of Na⁺- H⁺ antiporter gene is decreased by cortisol
C. The translation of mRNA of 1Na⁺- 3HCO₃⁻ symporter gene is decreased by cortisol
D. The secretion of endothelin-1 (ET-1) from the proximal tubule is enhanced in acidosis
E. ET-1 stimulates the phosphorylation and subsequent insertion of the Na⁺- H⁺ antiporter into the apical membrane of proximal tubular cells
F. The insertion of 1Na⁺- 3HCO₃⁻ symporter into the basolateral membrane of proximal tubular cells is also increased by ET-1
Choose all CORRECT statements from the following options:
Human chorionic gonadotropin (hCG) is a placental gonadotropin that controls hormonal secretions from corpus luteum during the initial stage of pregnancy. Following statements are made about hCG:
A. It is a glycoprotein that contains galactose and hexosamine.
B. It is a heterodimer with a larger alpha subunit and larger beta subunit.
C. It is a heterodimer with a smaller alpha subunit and larger beta subunit.
D. hCG is identical to beta subunit of LH and FSH.
E. It appears as early as 6 days after conception in blood and 14 days after conception in urine.
Which one of the following has all correct combination of statements?
Following statements are given for the ovarian hormones:
A. 17 β-estradiol, estrone and estriol are naturally occurring estrogens
B. They are 18 C steroids which do not have methyl group at 10th positions
C. They are 21 C steroids which have methyl group at 10th position
D. They are primarily synthesized by granulosa cells of the ovarian follicles
E. Their biosynthesis does not depend on the enzyme aromatase
Which one of the following options represents the combination of correct statements?
Which one of the following is used in organification of tyrosine residues in thyroglobulin protein, during thyroid hormone biosynthesis?
Plasma proteins have vital roles in the body ranging from maintaining osmolarity to transport of hormones. Certain statements are given below for the functions of selected plasma proteins:
A. Von Willebrand factor is normally synthesized in the liver.
B. Ceruloplasmin is a copper carrier protein.
C. Genetic deficiency of α₁-antiproteinase causes emphysema.
D. Most plasma proteins including albumin are covalently glycosylated.
E. α₁-acid glycoprotein (AGP) level increases during body’s response to inflammation.
Which one of the following represents all correct combinations of statements?
Insulin is a polypeptide hormone that reduces blood glucose levels in humans. The following statements are related to insulin synthesis and structure:
A. It is synthesized in the rough endoplasmic reticulum of B cells of islets of Langerhans.
B. It is synthesized in the cytosol on free ribosomes of B cells of islets of Langerhans.
C. Insulin has an AB heterodimer structure with one intrachain (A8–A13) and two interchain disulfide bridges (A6–B10 and A21–B18).
D. Insulin has an AB heterodimer structure with one intrachain (A6–A11) and two interchain disulfide bridges (A7–B7 and A20–B19).
E. The gene for insulin is located on the long arm of chromosome 11 and has two introns and three exons.
F. The gene for insulin is located on the short arm of chromosome 11 and has two introns and three exons.
Which one of the following combinations of statements is correct?
Mullerian-inhibiting substance (MIS), a homodimer that causes regression of the Mullerian duct by apoptosis, is secreted by which one of the following cells?
Given below are some statements about pituitary hormones:
A. Oxytocin and vasopressin are synthesized in posterior pituitary
B. Prolactin is synthesized from anterior pituitary
C. α and β MSH are secreted from intermediate lobe of pituitary in adult humans
D. Growth hormone secretion from anterior pituitary is stimulated by hyperglycemia
E. Prolactin secretion is markedly increased by sleep
Choose the INCORRECT combination of statements from below:
The mechanisms of action of calcitropic hormones are important for understanding the molecular basis of disease states related to calcium homeostasis.
A. Calcium binding (transport) protein (CaBP) enhances the movement of calcium from the brush border into the cytoplasm.
B. Receptors for calcitonin are present in the osteoclasts where they increase cAMP production.
C. Parathormone essentially works independently to mobilize bone mineral, and never in concert with vitamin D.
D. The major calctropic hormone, calcitriol, regulates intestinal calcium absorption.
Which one of the following options is INCORRECT in maintaining calcium homeostasis?
Given below are some statements about thyroid hormone biosynthesis in the thyroid gland.
A. An antiporter transports two Na+ ions and one I- ion across the thyroid follicular cells.
B. Pendrin, a Cl-/I- symporter helps I- entry into the colloid.
C. Pendrin, a Cl-/I- exchanger helps I- entry into the colloid.
D. Iodination of tyrosine residue takes place first on the 3rd position in the thyroglobulin protein.
Which one of the following options represents the combination of correct statements?