Correct option is C
Explanation-
Statement A: "Von Willebrand factor is normally synthesized in the liver." - Incorrect
Von Willebrand factor (vWF) is primarily synthesized by endothelial cells and megakaryocytes, not the liver. Although the liver synthesizes many plasma proteins, vWF is not one of them.
Statement B: "Ceruloplasmin is a copper carrier protein." - Correct
Ceruloplasmin is a copper-binding protein synthesized in the liver. It plays a key role in copper transport and has oxidase activity.
Statement C: "Genetic deficiency of α₁-antiproteinase causes emphysema." - Correct
α₁-antiproteinase (also known as α₁-antitrypsin) deficiency leads to uncontrolled activity of neutrophil elastase, damaging alveoli and causing early-onset emphysema.
Statement D: "Most plasma proteins including albumin are covalently glycosylated." - Incorrect
While many plasma proteins are glycosylated (especially glycoproteins), albumin is not glycosylated. Therefore, the generalization in this statement is false.
Statement E: "α₁-acid glycoprotein (AGP) level increases during body’s response to inflammation." - Correct
AGP is an acute-phase protein. Its levels increase significantly during inflammation, infections, and trauma.
Correct Combination: B, C, and E
That matches Option c.
