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​Mullerian-inhibiting substance (MIS), a homodimer that causes regression of the Mullerian duct by apoptosis, is secreted by which one of the followin
Question

Mullerian-inhibiting substance (MIS), a homodimer that causes regression of the Mullerian duct by apoptosis, is secreted by which one of the following cells?

A.

Leydig cells

B.

Sertoli cells

C.

Corpus luteal cells

D.

Placental cells

Correct option is B

Explanation-

Mullerian-inhibiting substance (MIS), also called Anti-Mullerian Hormone (AMH). It is part of the TGF-β (Transforming Growth Factor-beta) family. It  plays a crucial role in male sexual differentiation. During embryonic development in males, the Sertoli cells (found in the seminiferous tubules of the testes) secrete MIS/AMH. This hormone induces apoptosis in the Mullerian ducts, preventing the development of female internal genital structures like the uterus and fallopian tubes.

Incorrect Options-
Option A - Leydig cells – These secrete testosterone, not MIS. Testosterone supports the development of Wolffian ducts (male internal genitalia), not the regression of Mullerian ducts.
Option C - Corpus luteal cells – These are part of the female ovary, responsible for producing progesterone during the menstrual cycle, and have no role in secreting MIS.
Option D - Placental cells – The placenta secretes hormones like hCG, progesterone, and estrogen, but not MIS.

So, the correct answer is option B - Sertoli cells

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