Choose the correct answer from the options given below:

Sequentially arrange the following physiological responses to stress:
A. Increase in available energy
B. Release of ACTH
C. Release of glucocorticoids
D. Release of CRF

Correct option is D

The hypothalamic-pituitary-adrenal (HPA) axis is activated in response to stress, leading to a cascade of hormonal releases that help the body adapt.

D. Release of CRF (First Step - Hypothalamus Initiates Response)
Corticotropin-Releasing Factor (CRF) is secreted by the hypothalamus in response to stress.
CRF stimulates the pituitary gland to release ACTH.

B. Release of ACTH (Second Step - Pituitary Gland Response)
The pituitary gland releases Adrenocorticotropic Hormone (ACTH) into the bloodstream.
ACTH travels to the adrenal glands, stimulating the release of glucocorticoids.

C. Release of Glucocorticoids (Third Step - Adrenal Gland Response)
The adrenal cortex secretes glucocorticoids (e.g., cortisol) in response to ACTH.
Glucocorticoids help regulate metabolism and the immune response to cope with stress.

A. Increase in Available Energy (Final Step - Stress Adaptation)
Cortisol increases glucose availability, ensuring that the body has sufficient energy to handle the stressor.
This helps the body sustain heightened alertness and physical readiness.