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​Iron deficiency is a common problem in humans. The homeostasis of iron in the body is regulated by various proteins (Column X) and their functions (C
Question

Iron deficiency is a common problem in humans. The homeostasis of iron in the body is regulated by various proteins (Column X) and their functions (Column Y):

Choose the correct match between Column X and Column Y.

A.

A - i, B - iii, C - ii, D - iv

B.

A - iii, B - iv, C - ii, D - i

C.

A - ii, B - i, C - iv, D - iii

D.

A - iv, B - ii, C - iii, D - i

Correct option is B

Explanation-

A. Ferritin → iii. Intramucosal cell iron binding protein
Ferritin is a cellular protein that stores iron and releases it in a controlled fashion. In intestinal mucosal cells, it binds and stores iron, preventing excess free iron that could be toxic.
B. Ferroportin → iv. Iron leaves mucosal cells through it
 Ferroportin is the only known iron exporter protein in mammals. It is present on the basolateral side of enterocytes (intestinal cells), allowing iron to exit the cell into the bloodstream.
C. Transferrin → ii. Plasma iron binding protein
Transferrin is a glycoprotein that binds iron in plasma and transports it to various tissues.
D. Hepcidin → i. Hypoxia is known to reduce its synthesis
Explanation: Hepcidin is a liver-derived hormone that regulates systemic iron homeostasis. Under hypoxia or iron deficiency, hepcidin synthesis decreases to allow more iron absorption and mobilization.

So, the  correct option is (b) - A - iii ,B - iv, C - ii ,D - i

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