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    ​In mammals, autophagy is involved in specific cytosolic rearrangements needed for proliferation and differentiation during embryogenesis and postnata
    Question

    In mammals, autophagy is involved in specific cytosolic rearrangements needed for proliferation and differentiation during embryogenesis and postnatal development. Embryos have the ability to activate general protective strategy against many stress-inducing conditions. Which one of the following statements Does NOT conform to the role of autophagy during early development?

    A.

    Autophagy is a process of cytosolic renovation, crucial for cell fate decisions.

    B.

    Autophagy plays a dual role both in adaptation to stress and starvation during morphogenesis and in cell elimination along with apoptosis.

    C.

    Functional characterization of the autophagy regulatory genes indicates that autophagy is definitely not an evolutionarily conserved process.

    D.

    Defects in autophagy during early embryogenesis can be lethal for the organism.

    Correct option is C

    Explanation-

    Option A -  Autophagy is a process of cytosolic renovation, crucial for cell fate decisions - Correct.
    Autophagy removes damaged organelles and proteins. It supports proper cell fate decisions by maintaining cytoplasmic quality.
    Option B - Autophagy plays a dual role both in adaptation to stress and starvation during morphogenesis and in cell elimination along with apoptosis - Correct.
    Autophagy is activated under stress/starvation. It plays a key role in cell survival and cell death (when excessive), often complementing apoptosis.
    ​Option C - Functional characterization of the autophagy regulatory genes indicates that autophagy is definitely not an evolutionarily conserved process - Incorrect.
    Autophagy is a highly evolutionarily conserved process from yeast to humans. Its core components (like ATG genes) are well conserved.
    Option D - Defects in autophagy during early embryogenesis can be lethal for the organism -  Correct.
    Disruption of autophagy-related genes (like ATG5, Beclin1) can cause embryonic lethality in mice and other models.

     Final Answer: Option C is incorrect that makes it a correct answer

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