In eclampsia, the initial loading dose of intramuscular Inj MgSO₄ is–

Correct option is A

Sol. In eclampsia, the standard loading dose of magnesium sulfate (MgSO₄) is 4 grams IV over 5–10 minutes followed by 5 grams IM in each buttock, totaling 10 grams IM. This helps prevent further seizures. MgSO₄ is the drug of choice in eclampsia due to its anticonvulsant and neuroprotective effects.
Explanation of each option:
· (a) 5 grams in each buttock – Correct Answer. Standard protocol (Pritchard regimen) for loading dose after IV infusion. Given deeply to avoid tissue irritation.
· (b) 10 grams in each buttock – Overdose; may cause magnesium toxicity including respiratory depression, absent reflexes, and cardiac arrest.
· (c) 10 grams in single buttock – Unsafe; excessive volume and risk of tissue damage. Dose must be divided for safe absorption.
· (d) 5 grams in single buttock – Incomplete; only half the recommended loading dose, reducing effectiveness in seizure control.