Identify an absolute contraindication for thrombolytic therapy.

Correct option is B

A known bleeding disorder is an absolute contraindication for thrombolytic therapy, which involves the administration of drugs to dissolve blood clots. In patients with bleeding disorders, the risk of life-threatening hemorrhage significantly outweighs the potential benefit of clot resolution. Conditions like hemophilia or thrombocytopenia are key red flags before initiating thrombolytics.
Explanation of options: (a) Chest pain longer than 20 minutes – This is actually an indication for thrombolytic therapy, especially if related to myocardial infarction. (b) Known bleeding disorder – This is the correct answer. It poses a high risk for uncontrolled bleeding if thrombolytics are administered. (c) Recent administration of nitroglycerine – This is not a contraindication; nitroglycerine is often used alongside thrombolytics to relieve chest pain. (d) ST-segment elevation on the ECG – This is a key indication for thrombolytic therapy in acute myocardial infarction.