Cobblestone ulcerations in the bowel are seen in which of the following diseases?

Correct option is A

Ans. (a) Sol. Cobblestone ulcerations in the bowel are characteristic of Crohn’s disease, a chronic inflammatory bowel disease (IBD). This appearance is due to deep transmural inflammation, skip lesions, and linear ulcers, which create an irregular, cobblestone-like pattern on the intestinal mucosa. Crohn’s disease can affect any part of the gastrointestinal (GI) tract, from the mouth to the anus, but it most commonly involves the terminal ileum and colon.
Explanation of Other Options:
· (b) Intestinal obstruction: Does not cause cobblestone ulcerations; it is a mechanical or functional blockage that disrupts the movement of intestinal contents.
· (c) Malabsorption syndrome: Refers to impaired nutrient absorption due to conditions like celiac disease or pancreatic insufficiency but does not cause cobblestone ulcerations.
· (d) Ulcerative colitis: Unlike Crohn’s disease, ulcerative colitis causes continuous inflammation of the colonic mucosa, leading to superficial ulcers and pseudopolyps, rather than the deep, skip lesions with cobblestoning seen in Crohn’s disease.