Correct option is C
Tetanospasmin, the neurotoxin produced by Clostridium tetani, inhibits the release of gamma-aminobutyric acid (GABA) and glycine at synapses, causing spastic paralysis. This inhibitory neurotransmitter blockade leads to the characteristic muscle rigidity and spasms seen in tetanus. The other statements are correct: Tetanospasmin is associated with tetanus, it is a neurotoxin, and immunization with tetanus toxoid is a standard preventive measure.
Information Booster:
- Tetanospasmin blocks GABA and glycine release, causing spastic paralysis.
- It is one of the most potent neurotoxins known.
- Tetanus immunization uses an inactivated form of the toxin (toxoid).
- Tetanospasmin spreads via retrograde axonal transport to the central nervous system.
- The toxin's effects are irreversible without timely treatment.
Additional Knowledge:
- Tetanospasmin (Option a, b):
Tetanospasmin is a potent neurotoxin produced by Clostridium tetani. It enters motor neurons at the site of infection and travels retrogradely to the central nervous system. - Inhibition of GABA and Glycine (Option c):
Incorrect. Tetanospasmin prevents the release of inhibitory neurotransmitters (GABA and glycine) in the spinal cord and brainstem. This leads to sustained muscle contractions and spasms. It does not facilitate neurotransmitter release. - Toxoid Immunization (Option d):
Tetanus prevention relies on vaccination with tetanus toxoid, an inactivated toxin. Booster doses are necessary every 10 years to maintain immunity.
