Arrange the stages in endochondral ossification occurring in along bone.
A. Cartilage in the center of the diaphysis calcifies and then cavities
B. The periosteal bud invades the internal cavities and spongy bone forms
C. The epiphyses ossify
D. Formation of bone collar around hyaline cartilage model
E. The diaphysis elongates and medullary cavity forms
Choose the correct answer from the options given below:

Correct option is A

Explanation of Stages in Endochondral Ossification Endochondral ossification is the process by which cartilage is replaced by bone during the development of long bones. The stages occur in the following sequence:
1. Formation of bone collar around the hyaline cartilage model (D):
· This is the first step, where osteoblasts form a bone collar around the diaphysis (shaft) of the hyaline cartilage model to provide structural support.
2. Cartilage in the center of the diaphysis calcifies and then cavities (A):
· The cartilage matrix calcifies, causing chondrocytes to die, and cavities form within the diaphysis.
3. The periosteal bud invades the internal cavities and spongy bone forms (B):
· Blood vessels, along with nerves, osteoblasts, and osteoclasts, invade the cavities, and spongy bone starts forming.
4. The diaphysis elongates and the medullary cavity forms (E):
· Osteoclasts break down newly formed spongy bone to create the medullary cavity. This occurs as the diaphysis elongates.
5. The epiphyses ossify (C):
· Secondary ossification centers appear in the epiphyses, leading to ossification of the ends of the long bone.
Correct Sequence: D → A → B → E → C Correct Answer: (a) D, A, B, E, C
Information Booster: · Endochondral Ossification:
· Essential for the formation of long bones like the femur, humerus, and tibia.
· Occurs in two stages: primary ossification (diaphysis) and secondary ossification (epiphysis).
· Key Processes:
· Replacement of cartilage by bone.
· Formation of the medullary cavity for marrow development.
· Growth at epiphyseal plates during childhood and adolescence.